CYP2C19 gene polymorphism and omeprazole metabolism. Single and continual administration test.
نویسندگان
چکیده
منابع مشابه
Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite.
Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive prodrug that needs to be converted to an active metabolite in two sequential metabolic steps. Several CYP450 isoforms involved in these two steps have been described, although the relative contribution in vivo of each enzyme is still under debate. CYP2C19 is considered to be the major contributor to acti...
متن کاملEffect of polymorphism in CYP2C19 on Pharmacokinetics of Omeprazole in Indigenous Population
Omeprazole, a proton pump inhibitor (PPI) is one of the most widely prescribed drugs used world wide and is available over-the-counter in some countries. According to the results of numerous clinical studies, CYP2C19 polymorphisms is an important factor affecting the pharmacokinetics of most PPIs.According to some research,Asian populations is characterized by high prevalence of defect CYP2C19a...
متن کاملEffects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans.
BACKGROUND AND PURPOSE A triple therapy with omeprazole, amoxicillin (INN, amoxicilline), and clarithromycin is widely used for the eradication of Helicobacter pylori. Omeprazole and clarithromycin are metabolized by CYP2C19 and CYP3A4. This study aimed to elucidate whether clarithromycin affects the metabolism of omeprazole. METHODS After administration of placebo or 400 mg clarithromycin tw...
متن کامل[Influence of CYP2C19 polymorphism and Helicobacter pylori status on the antisecretory effect of omeprazole in gastroesophageal reflux disease].
BACKGROUND/AIMS The acid suppressive effect of omeprazole (OMP) is influenced by the metabolic capacity of gastric acid suppression, which is dependent on CYP2C19 polymorphism. The aim of this study was to determine the influence of CYP2C19 polymorphism and Helicobacter pylori (H. pylori) infection on the intragastric acid suppression of OMP. METHODS Thirty one patients with gastroesophageal ...
متن کاملGenetic Polymorphism of CYP2C19 in Pakistani Population
CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1997
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.28.167